Derivatives [ edit] 1,3,4-Oxadiazole itself is not commonly used in organic chemistry, but many of its derivatives are important. For example, raltegravir is an HIV drug which contains an 1,3,4-oxadiazole ring. Other pharmaceutical drugs containing the 1,3,4-oxadiazole ring include fenadiazole, zibotentan, and tiodazosin . filexlib. Five derivatives of each of 2,5-disubstituted and mannich bases of 1,3,4-oxadiazole were synthesized from acid hydrazides. The structures of the synthesized compounds were confirmed on the basis of IR, 1H NMR and Mass spectroscopy. All the compounds were screened for their in vitro antibacterial and antifungal activities. Semantic Scholar
Structurally, oxadiazole is a five-member heterocyclic ring that contains one oxygen and two nitrogen atoms as heteroatom. It is a well-known scaffold for its diverse biological activities like antiviral, antibacterial, antifungal, anti-inflammatory, antimycobacterial, anti-HIV, and anticancer, etc [ [10], [11], [12], [13], [14], [15], [16] ].
Synthesis, Characterization, and Biologic Activity of New Acyl Hydrazides and 1,3,4-Oxadiazole Derivatives Carmen C Diaconu Starting from isoniazid and carboxylic acids as precursors, thirteen new hydrazides and 1,3,4-oxadiazoles of 2- (4-substituted-phenoxymethyl)-benzoic acids were synthesized and characterized by appropriate means.
As we know that, Oxadiazole or furadi azole ring containing derivatives are an important class of heterocyclic com-pounds. A heterocyclic five-membered ring that possesses two carbons, one oxygen atom, two nitrogen atoms, and two double bonds is known as oxadiazole. They are derived from furan by the replacement of two methylene groups
To date, different methods have been developed for the synthesis of these heterocyles. The most straightforward synthesis relies on the cyclization of corresponding thiosemicarbazide derivatives with several desulfurating agents [], such as 1,3-dibromo-5,5-dimethylhydantoin []; p-tosyl chloride [24,25]; alkylating agents [26,27], such as methyl iodide and ethyl bromoacetate; carbodiimides [28 Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery. Five-membered 1,2,4-oxadiazole heterocyclic ring has received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities. Thus, it is a perfect framework for the novel drug development.
The structures of synthesized oxadiazole derivatives and their copper complexes were elucidated on the basis of FTIR, elemental analyses, 1H-NMR and atomic absorption spectral analysis. The synthesized compounds were further evaluated with biological activities and compared with parent hydrazones. Copper complexes
Synthesis of 1,3,4-oxadiazole derivatives from α-amino acid and acyl hydrazides under thermal heating or microwave irradiation conditions. Arkivoc 2015;7:131-44. 22. Bala S, Kamboj S, Kajal A, Saini V, Prasad DN. 1,3,4-Oxadiazole derivatives: Synthesis, Characterization, antimicrobial potential, and computational studies.
A radical-promoted cross-dehydrogenative coupling strategy enables a metal- and base-free one-pot synthesis of 2,5-diaryl 1,3,4-oxadiazoles via N -acylation of aryl tetrazoles with aryl aldehydes, followed by thermal rearrangement. A broad range of aryl tetrazoles and aryl aldehydes deliver the corresponding products in good yields.
Download Free PDF. Synthesis and Anticancer Evaluation of New 1,3,4-Oxadiazole Derivatives. A series of 5-(2-hydroxyphenyl)-3-substituted-2,3-dihydro-1,3,4-oxadiazole-2-thion