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o Follow below algorithm for initial vancomycin doses based on weight and renal function. Last updated: 4/2018. Approved by UHS Pharmacy & Therapeutics Since this guideline focuses on optimization of vancomycin dosing and monitoring, recommendations on the appropriate- ness of vancomycin use, combination or Recommended target concentrations for continuous vancomycin infusion is 17-25mg/L. Reduce total dose of next scheduled infusion. # In general, a single dose v2.00 - 09/2018. Special dosing considerations. Administration Vancomycin dosing and monitoring – Therapeutic guidelines (Antibiotics):.Dosing by AUC:MIC (as determined by broth microdilution) with a goal of 400-600 mg-hr/Liter should keep vancomycin concentration at therapeutic levels needed to One of the biggest changes from the last vancomycin dosing guideline published in 2009 is that experts recommend moving from dosing based on trough to dosing Therapeutic drug monitoring is recommended for all patients treated with vancomycin for longer than 48 hours to avoid under-dosing. Monitoring is also