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Quick Reference: GUIDELINE FOR PRIMARY CARE. MANAGEMENT OF HEADACHE IN ADULTS. September 2016. *LOC - loss of consciousness. Current practice guideline. Replaces "Pharmacological Treatment of Migraine Headache in Children and Adolescents" (December 2004). Endorsed by the Americanheadaches on underlying migraine, or medication recommended by a neurologist (link to guidance). Can occur on top of other types of headaches. Exclusions: •. This guideline does not provide recommendations for the management of patients with headache in the emergency department or inpatient setting.