Enriched domain annotations are those with a Q-value <0.01 after Benjamini-Hochberg correction of a two-sided binomial test. FIG. 2C is a pair of graphs showing (top) overlap between in situ HHS-465- and HHS-475-modified tyrosine sites that are also phosphorylation sites (number of phosphotyrosine high throughput annotation on PhosphoSitePlus