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for sterile pharmaceutical products. 1. General considerations. 2. Quality control. 3. Sanitation. 4. Manufacture of sterile preparations. 5. Sterilization.This guidance document describes the current basic concepts on sterility assurance and associated procedures for manufacturing and controlling sterile Sanitization: Cleansing technique that mechanically METHODS. Sterilization and disinfection are done by : jelly and some pharmaceutical products. A . Physical methods: 1.Heat sterilization: a . Dry heat sterilization b . Moist heat sterilization. 2 . Sterilization by radiation. PHARMACEUTICAL. MICROBIOLOGY. Sterilization Methods and. Principles. 1. Introduction. Sterilization can be defined as: any process that effectively kills or