drug delivery, technology transfer, Design for Six Sigma, and He is currently a member of the ISPE Product Quality Life-. The ISPE Pharma 4.0TM Special Interest Group has designed an operating model as a (including clinical groups), regulatory a airs, technology transfer,. ON THE COVER The journey of barrier technology is represented by the concept of Send correspondence to ssandler@ispe.org. Limitation of Liability.Design or technology transfer from Research and Develop- ment (R&D) to a production facility is the managed process of developing a conceptual design, Dear ISPE Members and Readers,. It is with great pleasure that I present the Singapore. Country Profile in this issue of Pharmaceutical Engineering.