Detalles Bibliográficos; Título: Gammaherpesviruses and Lymphoproliferative Disorders. Autores: Cesarman, Ethel: Fuente: Annual Review of Pathology; 2014, Vol. 9 PDF + Supplementary gammaherpesviruses consistently associated with the development of human malignancies. EBV is most frequently associated with subsets of Hodgkin, non-Hodgkin's lymphomas (NHL) and a few epithelial malignancies. Conversely, KSHV is the causal agent of Kaposi's sarcoma (KS) and a few rare lymphoproliferative disorders. EBV and KSHV are more often associated with cancers Gammaherpesviruses (GHVs) are a large group of dsDNA viruses that can infect humans and several animal species. The two human GHVs, Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus are known for their oncogenic properties in individuals with immunodeficiency. Recently, the first feline GHV, Felis catus gammaherpesvirus 1 (FcaGHV1) was discovered and frequently found in domestic The viruses cause a range of disease conditions in humans and animals, such as lymphoproliferative disorders, including lymphoma and nonlymphoid cancers (Ackermann 2006). Evidence for the presence of GHVs in felid species has included detection of a GHV DNA sequence in an African lion ( Panthera leo ; Ehlers et al. 2008 ) and detection of bovine herpesvirus 4 in domestic cats ( Felis catus The human gammaherpesviruses, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), are both associated with tumors. Standard antiviral therapies are ineffective at treating these tumors. A serine/threonine kinase important for viral replication is conserved across the herpesviruses. Since its discovery as the first human tumor virus, EBV has been implicated in the development of a wide range of B-cell lymphoproliferative disorders, including Burkitt lymphoma (BL), nasopharyngeal carcinoma, and Hodgkin and non-Hodgkin lymphomas (NHLs). Open Access | Two lymphotropic human gamma herpesviruses can cause lymphoproliferative disorders: Epstein Barr virus (EBV, formally designated as human herpesvirus 4) and Kaposi sarcoma herpesvirus (KSHV, also called human herpesvirus 8). Individuals with inherited or acquired immunodeficiency have a greatly increased risk of developing a malignancy caused by one of these two viruses. Figure 2 Histopathology of Epstein-Barr virus (EBV)-associated diseases. (Top row) Hematoxylin and eosin (H&E)-stained sections of tissues involved by posttransplantation lymphoproliferative disorders are shown. These include examples of a plasmacytic hyperplasia (PH), showing a majority of mature reactive lymphocytes with some immunoblasts and plasma cells; a polymorphic lymphoproliferative Murine Gammaherpesvirus 68 Infection Is Associated with Lymphoproliferative Disease and Lymphoma in BALB 2 Microglobulin-Deficient Mice. Journal of Virology, 2005 . Felipe Suarez. Download Download PDF. Full PDF Package Download Full PDF Package. This Paper. A short summary of this paper. 36 Full PDFs related to this paper. Read Paper. Download Download PDF. Download Full PDF Package Murine gammaherpesvirus is a natural pathogen of wild rodents. In the laboratory it establishes an infection of epithelial cells and persists in B lymphocytes in a latent form. Inbred mice chronically infected with the virus develop a l