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Managing potentially problematic studies. Cochrane Reviews are high quality systematic reviews that aim to provide the best available evidence of the effects This fully updated edition contains extensive new material on systematic review methods addressing a wide-range of topics including network meta-analysis, Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022). Cochrane, 2022. Available from training.cochrane.org/handbook This work is a co-publication between The Cochrane Collaboration and John Wiley & Sons Ltd. Edition History. 1e The Cochrane Collaboration. We followed the Cochrane Collaboration guideline of conducting a systematic review for economic evidence [11] and consulted with other recommendations [12][