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Organisms develop resistance faster to the natural antimicrobials because they have been pre-exposed to these compounds in nature. Natural antibiotics are often Classification of antimicrobial agents. 1.Based on mechanism of action. 2.Based on therapeutic use/ organisms affected. 3.Based on spectrum of activity. C. Classes of antibiotics. 1. β-Lactam antibiotics examples: penicillins (e.g. amoxicillin), cephalosporins, carbapenems, monobactams, etc. 2. Tetracyclines. Antibiotics are usually classified or grouped by their chemical structure. Some antibiotic classes work by killing bacteria. The classification of antibiotics and their mode of action are reviewed with emphasis on molecular perspectives to safeguard man's healthcare delivery Table 1 | Main classes of antibiotics. Class. Examples β-Lactams. Penicillins. Penicillin G, penicillin V, methicillin, oxacillin, cloxacillin,.Classification Cephalosporins are classifi ed on the basis of their chemical structure, clinical pharmacology, antibacterial spectrum, or penicillinase