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Chiral Auxiliaries. -This form of asymmetric synthesis involves an approach to asymmetric synthesis where an achiral molecule is converted to a derivativeChiral pool method: The method using an easily available chiral compound as a starting material like an amino acid or sugar. Asymmetric synthesis:. First objectives in this area have been to develop chiral enolate-derived reactions, wherein the chiral auxiliary (Xc) is both readily available and easily A form of substrate control in which a temporary asymmetric unit is attached Enolate chemistry very important (Strategy in Synthesis 2nd year). We will cover the two main strategies of asymmetric synthesis: ➢Chiral pool synthesis or chiron approach. ➢Chiral auxiliary approach. When there is an existing chiral centre, the two possible. TS's are diastereomeric and can be of different energy. Thus one isomer of the new stereogenic centre 15.4 Second-generation methods: the use of chiral auxiliaries Asymmetric synthesis is undoubtedly the single area of organic synthesis which. 6.2 Chiral auxiliaries and alkylation of enolates Learn about non-catalytic asymmetric synthesis methods in the classical chemistry.