Gale Academic OneFile includes The immunopathogenesis of sepsis by Jonathan Cohen. Read the beginning or sign in for the full text. filexlib. The Immunopathogenesis of Sepsis in Elderly Patients Steven M. Opal, Timothy D. Girard, E. Wesley Ely Clinical Infectious Diseases, Volume 41, Issue Supplement_7, November 2005, Pages S504-S512, doi.org/10.1086/432007 Published: 15 November 2005 PDF Split View Cite Permissions Share Abstract Sepsis is a condition that results from a harmful or damaging host response to infection. Many of the components of the innate immune response that are normally concerned with host defences against infection can, under some circumstances, cause cell and tissue damage and hence multiple organ failure, the clinical hallmark of sepsis.
cecal ligation and puncture (CLP) mediated sepsis and Pseudomonas aeruginosa (Pa)-lipopolysacharride (Pa-LPS) induced acute lung injury (ALI) models to verify if these early-age-related changes aggravate the inflammatory pathophysiology. Sepsis or septic shock is the major risk factor for mortality in the aged population [33].
molecular events function in concert to render elderly patients at excess risk for mortality from severe sepsis and septic shock. The incidence of sepsis and its attendant mortality risk are both increased significantly with advanced age. The majority of the 750,000 patients who develop sepsis each year in the United States are aged >65 years [1].
[PDF] The immunopathogenesis of sepsis in elderly patients. | Semantic Scholar The induction of proinflammatory cytokines after septic stimuli is not adequately controlled by anti-inflammatory mechanisms in elderly persons and this immune dysregulation is accompanied by a more pronounced procoagulant state in older patients.
and on the importance of recognizing sepsis as a preventable and time-critical condition with urgent therapeutic need, and of communicating with patients, relatives and other parties using the term "sepsis" in order to enhance public awareness; (7) to promote research aimed at innovative means of diagnosing and treating sepsis across Cohen, J. (2002) The immunopathogenesis of sepsis. Nature, 420, 885-891. doi:10.1038/nature01326 has been cited by the following article: TITLE: Cytokine release in sepsis AUTHORS: Ian Burkovskiy, Joel Sardinha, Juan Zhou, Christian Lehmann KEYWORDS: Sepsis; Cytokine; Inflammation; Immunology
hways of complement and the activation products of complement, especially the anaphylatoxin C5a and its receptors, C5aR1 and C5aR2. Much has also been learned about these pathways of activation that trigger activation of the innate immune system and the array of strong proinflammatory cytokines that can cause cell and organ dysfunction, as well as complement products that cause
The immunopathogenesis of sepsis in elderly patients The immunopathogenesis of sepsis in elderly patients Authors Steven M Opal 1 , Timothy D Girard , E Wesley Ely Affiliation 1 Infectious Disease Division, Brown University School of Medicine, Providence, Rhode Island, USA. Steven_Opal@brown.edu PMID: 16237654 DOI: 10.1086/432007 Abstract
were hospitalized with sepsis in 2008, corresponding to an incidence of 32.7/10 000 patients, a 70% increase compared with that in 2000. Between 2004 and 2009 the sepsis case fatality rate in the United States of America ranged from 14.7% to 29.9%. The financial burden due to sepsis has been calculated
Elderly people are at increased risk for sepsis and sepsis-associated hospitalizati