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2 receptor-specific antagonists Losartan or PD-123319, respectively. Nonspecific binding was determined in the presence of 10 M unlabeled angiotensin II. Immunoblot Detection of AT 1 and AT 2 Receptors on Cells and on Myometrial Tissue Samples—The amount of AT 1 and AT 2 receptor protein on cells and myometrial tissue samples was determined in immunoblot with receptor-specific antibodies Angiotensin II Receptor Antagonists Potential in Elderly Patients with Cardiovascular Disease Louise M. Burrell & Colin I. Johnston Drugs & Aging 10 , 421-434 ( 1997) Cite this article 52 Accesses 22 Citations Metrics Summary Angiotensin II has been confirmed to facilitate cancer cell progression and metastasis. In this study, the possible anti-metastatic effects of an angiotensin II receptor type 1 (AT1R) antagonist, valsartan, have been investigated in an experimental CRC lung metastasis model. Methods Metabolism and disposition of irbesartan, an angiotensin II AT(1) receptor antagonist, were investigated in mice, rats, rabbits, and macaques. In both rats and macaques, irbesartan was characterized by a rapid oral absorption, a large volume of distribution, a low plasma clearance, and a long terminal half-life. Angiotensin II (AT-II)-receptor antagonists are reviewed. Research focused on blocking the renin-angiotensin system (RAS) led to the discovery of angiotensin-converting-enzyme (ACE) inhibitors, which are effective in the treatment of hypertension but are associated with a high frequency of cough and other adverse effects. Angiotensin II (AII) receptor antagonists (also known as angiotensin receptor blockers (ARBs) or AT. 1-receptor (AT1R) antagonists) constitute a therapeutic group which modulates the renin-angiotensin-aldosterone system (RAAS). Their main use is in the treatment of patients with hypertension. ARBs are also authorised in other indications, such as the treatment of chronic heart failure, recent Angiotensin II receptor antagonists block the vasoconstrictor and aldosterone- secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues (e.g. vascular smooth muscle, adrenal gland). Angiotensin II receptor antagonist-related fetopathy was suspected, and treatment was changed to a beta blocker (metoprolol) at 26 weeks 5 days' gestation. Subsequently, the amount of amniotic fluid increased to normal values, and further pregnancy was uneventful. Angiotensin II receptor blockers (ARBs), formally angiotensin II receptor type 1 (AT 1) antagonists, also known as angiotensin receptor blockers, angiotensin II receptor antagonists, or AT 1 receptor antagonists, are a group of pharmaceuticals that bind to and inhibit the angiotensin II receptor type 1 (AT 1) and thereby block the arteriolar contraction and sodium retention effects of renin ANGIOTENSIN II RECEPTOR ANTAGONIST (ARB) DOSING: TOOL FOR SWITCHING BETWEEN AGENTS IN CANADA ©2018 Canadian Pharmacists Association The information provided is intended to help prescribers select an alterna